منابع مشابه
Epidermal Growth Factor Receptor Pathway
Erlotinib is an orally small molecule inhibiting the tyrosine kinase activity of the epidermal growth factor receptor (EGFR). Currently, erlotinib, at a standard oral daily dose of 150 mg, is licensed for the treatment of unselected recurrent non-small cell lung cancer (NSCLC) patients, however, it is being investigated in all stages of NSCLC. Erlotinib is well tolerated, with common toxicities...
متن کاملVascular endothelial growth factor pathway.
New blood vessel formation (angiogenesis) is essential for the processes of tumor growth, invasion, and metastatic dissemination,1 and agents that inhibit this pathway, such as bevacizumab, have proven anticancer activity.2 Interactions between tumorand stroma-produced vascular endothelial growth factor (VEGF) ligands (particularly VEGF-A) and receptors (particularly VEGF receptor [VEGFR] 2) ar...
متن کاملSequential Use of Fibroblastic Growth Factor 2 and Transforming Growth Factor 1 in Cartilage Tissue Engineering Using Canine Chondrocytes
This study investigated the effect of fibroblast growth factor 2 in monolayer followed by transforming growth factor 1 in 3-dimensional culture on chondrocytic matrix production. Under the culture conditions presented, FGF2 is mitogenic but not chondrogenic. In addition, TGF 1 stimulation produced predominantly type I collagen.
متن کاملThe Relationship Between Fibroblastic Growth Factor Receptor-1 (FGFR1) Gene Amplification in Triple Negative Breast Carcinomas and Clinicopathological Prognostic Factors
Background & Objective: In Triple-Negative Breast Cancers (TNBCs), estrogen receptor (ER), progesterone receptor (PR) and HER2/neu genes are not expressed. Fibroblastic Growth Factor Receptor-1 (FGFR1) gene product is a protein that acts as a receptor of thyrosin kinase. It plays a role in the proliferation, differentiation, and migration of malignant cells. The objective was t...
متن کاملEffect of Fibroblastic Growth Factor on Resumption of Meiosis, In Vitro Maturation And Embryo Development of Immature Mouse Oocytes
Purpose: The purpose of this study was to evaluate the effect of fibroblastic growth factor on resumption of meiosis, in vitro maturation of immature mouse oocytes and resulting embryo development with and without basic fibroblastic growth factor-4 (bFGF-4). Materials and Methods: cumulus – oocyte complex (COCs) and germinal vesicle (GV) were obtained from female NMRI mice 46-48 hours after adm...
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ژورنال
عنوان ژورنال: Journal of Thoracic Oncology
سال: 2009
ISSN: 1556-0864
DOI: 10.1097/01.jto.0000361753.86918.40